The Serum IgG test measures the total concentration of Immunoglobulin G (IgG) antibodies circulating in your blood. Immunoglobulins are protective proteins produced by your plasma cells as part of your immune system’s defensive matrix. IgG is the most abundant type of antibody found in human plasma, accounting for approximately 75% to 80% of all immunoglobulins in the body. While other antibodies like IgM manage early, acute threats, IgG is responsible for providing long-term, sustained protection against viruses and bacteria. Measuring serum IgG levels serves as a vital diagnostic window to confirm long-term immune memory, evaluate vaccine efficacy, and identify deep-seated antibody deficiencies or autoimmune disorders. 🛡️🧬📊

When is this test performed and for which diseases? 🤔

• To Diagnose Immunodeficiency Disorders: This test is performed when a patient suffers from recurrent, severe, or atypical infections (such as chronic sinusitis or pneumonia) to diagnose Primary Immunodeficiency or selective IgG subclass deficiencies. 🚨📉

• To Screen for Plasma Cell Malignancy: It is ordered alongside serum protein electrophoresis (SPEP) when a patient presents with bone pain, unexplained anemia, or high total protein levels to screen for disorders like Multiple Myeloma or monoclonal gammopathies. 🩻🔬

• To Investigate Autoimmune and Inflammatory Conditions: This examination is performed to monitor chronic, active systemic conditions such as Systemic Lupus Erythematosus (SLE), rheumatoid arthritis, or IgG4-related systemic disease. 🩹📈

• To Confirm Long-Term Vaccine or Pathogen Response: It is performed to verify whether an individual has developed an adequate long-term immune memory following past immunizations or to check for past exposure to specific historical infections. 💉🔍

Test Specifications: 📋

• Sample Type: Blood (Serum) 🩸

• Preparation: No fasting is required; you can walk into the laboratory and give your sample at any time of the day. ☀️

• Reporting: High-precision quantitative nephelometric or turbidimetric laboratory results are typically delivered within 24 hours. ⏱️